The International Space Station's (ISS) Expedition 59 begins with the scheduled undocking of Soyuz MS-10. New crew members will arrive shortly thereafter on Soyuz MS-12.

Expedition 59 will include crew members Oleg Kononenko and Oleg Skripochka with Roscosmos; Anne McClain and Christina Hammock-Koch of NASA; and David Saint-Jacques with the Canadian Space Agency.