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Forum:Space Shuttles - Space Station
Topic:[ISS] First yearlong mission [Kelly, Kornienko]
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Robert PearlmancollectSPACE
Year-in-space astronaut Scott Kelly packs for home but skips souvenir

Scott Kelly isn't bringing home a souvenir of his year in space.

The NASA astronaut, who has been living and working on the International Space Station since March 2015, is set to return home to Earth on Tuesday (March 1) after 340 days circling the planet. Kelly is the first American to embark on such a long mission and, together with Russian cosmonaut Mikhail Kornienko is the first to stay for nearly a year at the orbiting outpost.

"I don't look at souvenirs that have been flown in space the same [way] that other people do, only because I've been in space so many times," Kelly explained Thursday (Feb. 25) in a press conference from the space station. "I absolutely understand why other people do and I respect that, but the fact that I've been here four times and well over 500 days, it doesn't have the same meaning to me."

Robert PearlmancollectSPACE
Scott Kelly and Mikhail Kornienko land on Earth after yearlong space mission

An astronaut and a cosmonaut who spent nearly one year on the International Space Station are now back on Earth.

Scott Kelly of NASA and Mikhail Kornienko of Roscosmos touched down on the snow-covered steppe of Kazakhstan on Russia's Soyuz TMA-18M spacecraft. Their landing, at 10:26 p.m. CST on Tuesday (March 1; 0426 GMT or 10:26 a.m. local time March 2), marked the historic completion of their 340-day expedition.

Sergey Volkov, who had been on the space station for the six months since Sept. 2, landed with Kelly and Kornienko southeast of the Kazakh town of Dzhezkazgan.

Robert PearlmancollectSPACE
Scott Kelly reflects on return to Earth after record 340 days in space

Scott Kelly took a breath in and smelled something he didn't recognize.

"It smells like a fragrance, like a plant was blooming in that area," the NASA astronaut said, recalling his first moments being back on the Earth after nearly a year in space.

"The air was refreshing because it was cool — and it was different than the air I experienced for the last 340 days," he said. "[But] that was the smell of burning Soyuz. It is the charred smell of the Soyuz. It has kind of a sweet smell to it."

Robert PearlmanNASA release
NASA's Landmark Twins Study Reveals Resilience of Human Body in Space

Results from NASA's landmark Twins Study, which took place from 2015-2016, were published Thursday in Science. The integrated paper — encompassing work from 10 research teams — reveals some interesting, surprising and reassuring data about how one human body adapted to — and recovered from — the extreme environment of space.

The Twins Study provides the first integrated biomolecular view into how the human body responds to the spaceflight environment, and serves as a genomic stepping stone to better understand how to maintain crew health during human expeditions to the Moon and Mars.

Retired NASA astronauts Scott Kelly and his identical twin brother Mark, participated in the investigation, conducted by NASA's Human Research Program. Mark provided a baseline for observation on Earth, and Scott provided a comparable test case during the 340 days he spent in space aboard the International Space Station for Expeditions 43, 44, 45 and 46. Scott Kelly became the first American astronaut to spend nearly a year in space.

"The Twins Study has been an important step toward understanding epigenetics and gene expression in human spaceflight," said J.D. Polk, chief Health and Medical Officer at NASA Headquarters. "Thanks to the twin brothers and a cadre of investigators who worked tirelessly together, the valuable data gathered from the Twins Study has helped inform the need for personalized medicine and its role in keeping astronauts healthy during deep space exploration, as NASA goes forward to the Moon and journeys onward to Mars."

Key results from the NASA Twins Study include findings related to gene expression changes, immune system response, and telomere dynamics. Other changes noted in the integrated paper include broken chromosomes rearranging themselves in chromosomal inversions, and a change in cognitive function. Many of the findings are consistent with data collected in previous studies, and other research in progress.

The telomeres in Scott's white blood cells, which are biomarkers of aging at the end of chromosomes, were unexpectedly longer in space then shorter after his return to Earth with average telomere length returning to normal six months later. In contrast, his brother's telomeres remained stable throughout the entire period. Because telomeres are important for cellular genomic stability, additional studies on telomere dynamics are planned for future one-year missions to see whether results are repeatable for long-duration missions.

A second key finding is that Scott's immune system responded appropriately in space. For example, the flu vaccine administered in space worked exactly as it does on Earth. A fully functioning immune system during long-duration space missions is critical to protecting astronaut health from opportunistic microbes in the spacecraft environment.

A third significant finding is the variability in gene expression, which reflects how a body reacts to its environment and will help inform how gene expression is related to health risks associated with spaceflight. While in space, researchers observed changes in the expression of Scott's genes, with the majority returning to normal after six months on Earth. However, a small percentage of genes related to the immune system and DNA repair did not return to baseline after his return to Earth. Further, the results identified key genes to target for use in monitoring the health of future astronauts and potentially developing personalized countermeasures.

"A number of physiological and cellular changes take place during spaceflight," said Jennifer Fogarty, chief scientist of the Human Research Program at NASA's Johnson Space Center in Houston. "We have only scratched the surface of knowledge about the body in space. The Twins Study gave us the first integrated molecular view into genetic changes, and demonstrated how a human body adapts and remains robust and resilient even after spending nearly a year aboard the International Space Station. The data captured from integrated investigations like the NASA Twins Study will be explored for years to come."

Part of the record-setting one-year mission, the NASA Twins Study incorporated 10 investigations to advance NASA's mission and benefit all of humanity. Scott participated in a number of biomedical studies, including research into how the human body adjusts to known hazards, such as weightlessness and space radiation. Meanwhile, Mark participated in parallel studies on Earth to help scientists compare the effects of space on a body down to the cellular level. The findings represent 27 months of data collection.

The Twins Study helped establish a framework of collaborative research that serves as a model for future biomedical research. Principal investigators at NASA and at research universities across the nation initiated an unprecedented sharing of data and discovery. Supported by 84 researchers at 12 locations across eight states, the data from this complex study was channeled into one inclusive study, providing the most comprehensive and integrated molecular view to date of how a human responds to the spaceflight environment. While significant, it is difficult to draw conclusions for all humans or future astronauts from a single test subject in the spaceflight environment.

"To our knowledge, this team of teams has conducted a study unprecedented in its scope across levels of human biology: from molecular analyses of human cells and the microbiome to human physiology to cognition," said Craig Kundrot, director, Space Life and Physical Sciences Research and Application Division at NASA Headquarters. "This paper is the first report of this highly integrated study that began five years ago when the investigators first gathered. We look forward to the publication of additional analyses and follow-up studies with future crew members as we continue to improve our ability to live and work in space and venture forward to the Moon and on to Mars."

The unique aspects of the Twins Study created the opportunity for innovative genomics research, propelling NASA into an area of space travel research involving a field of study known as "omics," which integrates multiple biological disciplines. Long-term effects of research, such as the ongoing telomeres investigation, will continue to be studied.

NASA has a rigorous training process to prepare astronauts for their missions, including a thoroughly planned lifestyle and work regime while in space, and an excellent rehabilitation and reconditioning program when they return to Earth. Thanks to these measures and the astronauts who tenaciously accomplish them, the human body remains robust and resilient even after spending a year in space.

See here for discussion of the space station's first yearlong mission.

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